 |
||
|---|---|---|
| 【ProductName】 |
CMTM6 Antibody Blocking Peptide |
|
| 【Cat NO.】 |
K114661P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
|
| 【Swiss Prot】 |
Q9NX76 |
|
| 【Gene ID】 |
54918 |
|
| 【Application】 |
Blocking Peptide of K114661P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
|
|
||
Background：
Master regulator of recycling and plasma membrane expression of PD-L1/CD274， an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes， where it protects PD-L1/CD274 from being targeted for lysosomal degradation， likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279， its receptor on T-cells， ultimately triggering T-cell anergy.