Background：

This gene encodes a member of the granzyme subfamily of proteins， part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease， which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins， and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis.