Background：

Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis， glial differentiation of neuroprogenitor cells， cell death of cardiomyocytes， adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay. Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs， such as IL6 and IL12B， during the early phase of inflammation. Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation， such as those encoding cytokines (IL6 and IL2)， cell surface receptors (ICOS， TNFRSF4 and TNFR2) and transcription factor (REL) (By similarity).