 |
||
|---|---|---|
| 【ProductName】 |
BAX Antibody Blocking Peptide |
|
| 【Cat NO.】 |
K106624P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
|
| 【Swiss Prot】 |
Q07812 |
|
| 【Gene ID】 |
581 |
|
| 【Application】 |
Blocking Peptide of K106624P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
|
|
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Background：
Plays a role in the mitochondrial apoptotic process. Under normal conditions， BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL， which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions， undergoes a conformation change that causes translocation to the mitochondrion membrane， leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3， and thereby apoptosis.7