Background：

This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions， including cytokinesis， cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17， Epstein syndrome， Alport syndrome with macrothrombocytopenia， Sebastian syndrome， Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness.