Background：

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD， and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation， survival and migration of endothelial cells， and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC， and to a lesser degree VEGFA， thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis.