Background：

This gene is a member of the cadherin superfamily， genes encoding calcium-dependent， membrane-associated glycoproteins. The encoded protein is cadherin-like， consisting of an extracellular region， containing 7 cadherin domains， and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts， acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants.