Background：

Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore.mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover， probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression， mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function， and in skeletal muscle stem cell differentiation.