Background：

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein， which has intrinsic GTPase activity， is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer， follicular thyroid cancer， autoimmune lymphoproliferative syndrome， Noonan syndrome， and juvenile myelomonocytic leukemia.