 |
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|---|---|---|
| 【ProductName】 |
TCF7L2 Antibody Blocking Peptide |
|
| 【Cat NO.】 |
K107478P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
|
| 【Swiss Prot】 |
Q9NQB0 |
|
| 【Gene ID】 |
6934 |
|
| 【Application】 |
Blocking Peptide of K107478P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
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Background：
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1， and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5’-CCTTTGATC-3’ in the presence of CTNNB1. TLE1， TLE2， TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.