Background：

The protein encoded by this gene is the CD3-epsilon polypeptide， which together with CD3-gamma， -delta and -zeta， and the T-cell receptor alpha/beta and gamma/delta heterodimers， forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon， gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.