Background：

Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-， C20:1- and C20:4-ceramides， dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:20068046， PubMed:26792856， PubMed:20207939， PubMed:11356846). Ceramides， sphingosine， and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation， apoptosis and differentiation (PubMed:20068046). Controls the generation of sphingosine in erythrocytes， and thereby sphingosine-1-phosphate in plasma (PubMed:20207939). Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function (By similarity). By regulating the levels of proinflammatory ceramides in immune cells and tissues， may modulate the inflammatory response (By similarity).