Background：

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif， the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box)， which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains， Fbls containing leucine-rich repeats， and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and， in addition to an F-box， contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus.