Background：

The protein encoded by this gene binds to an anti-proliferative protein， B-cell translocation protein 1， which negatively regulates cell proliferation. Binding of the two proteins， which is driven by phosphorylation of the anti-proliferative protein， causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X.