Background：

Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus， functions as a nuclear receptor coactivator regulating glucocorticoid， androgen， mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth， proliferation， migration， differentiation and senescence. May have a zinc-dependent DNA-binding activity.