Background：

Essential component of the BHC complex， a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones， thereby acting as a chromatin modifier. In the BHC complex， it serves as a molecular beacon for the recruitment of molecular machinery， including MeCP2 and SUV39H1， that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses， via histone deacetylase (HDAC) recruitment， a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.