Background：

This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium， sodium， and chloride channels， suggesting an involvement in the regulation of processes such as cell survival， neuronal excitability， and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.