 |
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|---|---|---|
| 【ProductName】 |
TNFRSF1B Antibody Blocking Peptide |
|
| 【Cat NO.】 |
K108916P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
|
| 【Swiss Prot】 |
P20333 |
|
| 【Gene ID】 |
7133 |
|
| 【Application】 |
Blocking Peptide of K108916P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
|
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Background：
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins， c-IAP1 and c-IAP2， which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown， however， c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2， which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.