Background：

DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye， bones， cardiovascular， kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5’-[G/C][A/T]AAA[T/C]AA[A/C]-3’ in promoter of target genes. Upon DNA-binding， promotes DNA bending. Acts as a transcriptional coactivator. Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2， and hence regulates endochondral ossification (By similarity). Acts also as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells. Regulates FOXO1 through binding to a conserved element， 5’-GTAAACAAA-3’ in its promoter region， implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye. Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity