Background：

Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging， transcription regulation， pre-mRNA splicing， and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families， methylates histone H3 at ’Arg-17’ (H3R17me)， forming mainly asymmetric dimethylarginine (H3R17me2a)， leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation， acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1， NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation， acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation， acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG， promotes adipocyte differen