 |
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|---|---|---|
| 【ProductName】 |
ZNF598 Antibody Blocking Peptide |
|
| 【Cat NO.】 |
K109259P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
|
| 【Swiss Prot】 |
Q86UK7 |
|
| 【Gene ID】 |
90850 |
|
| 【Application】 |
Blocking Peptide of K109259P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
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Background：
E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC)， a pathway that takes place when a ribosome has stalled during translation. Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40S ribosomal protein RPS10/eS10， RPS20/uS10 and RPS3/uS3. Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide. Also acts as a component of the 4EHP-GYF2 complex， a multiprotein complex that acts as a repressor of translation initiation.