Background：

this protein family (Ikaros， Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers， Ikaros/Aiolos heterodimers， and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described， as well as some non-protein coding variants.