 |
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|---|---|---|
| 【ProductName】 |
PRPF19 Antibody Blocking Peptide |
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| 【Cat NO.】 |
K109613P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
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| 【Swiss Prot】 |
Q9UMS4 |
|
| 【Gene ID】 |
27339 |
|
| 【Application】 |
Blocking Peptide of K109613P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
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Background：
Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770， PubMed:28076346， PubMed:29360106， PubMed:29301961， PubMed:30705154). Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly， its remodeling and is required for its activity. During assembly of the spliceosome， mediates ’Lys-63’-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex (PubMed:20595234). Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA， it may also couple the transcriptional and spliceosomal machineries (PubMed:21536736). The XAB2 complex， which contains PRPF19， is also involved in pre-mRNA splicing， transcription and transcription-coupled