 |
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|---|---|---|
| 【ProductName】 |
SLC8B1 Antibody Blocking Peptide |
|
| 【Cat NO.】 |
K109657P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
|
| 【Swiss Prot】 |
Q6J4K2 |
|
| 【Gene ID】 |
80024 |
|
| 【Application】 |
Blocking Peptide of K109657P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
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Background：
Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion， by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762， PubMed:22829870， PubMed:23056385， PubMed:24898248， PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival， notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion， thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca2+?entry (SOCE) and Ca2+?release-activated Ca2+?(CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status， thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyt