Background：

This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain， two Raf-like Ras-binding domains (RBDs)， and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding， through its GoLoco domain， to specific types of activated， GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP)， the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers， forming inactive G-protein heterotrimers， thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.