Background：

Receptor for Wnt proteins (PubMed:9054360， PubMed:10097073， PubMed:20530549). Can activate WNT2， WNT10B， WNT5A， but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (By similarity). In neurons， activation of WNT7A promotes formation of synapses (PubMed:20530549). Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins， inhibition of GSK-3 kinase， nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members， but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway， as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercell