Background：

Transcriptional regulator involved in different processes such as glucose metabolism， aerobic glycolysis， muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5’-GTAAACA-3’) and can both act as a transcription activator or repressor， depending on the context (PubMed:17670796). Together with FOXK2， acts as a key regulator of metabolic reprogramming towards aerobic glycolysis， a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2)， phosphofructokinase， pyruvate kinase (PKLR) and lactate dehydrogenase)， while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting， when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in