 |
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|---|---|---|
| 【ProductName】 |
ARPC1B Antibody Blocking Peptide |
|
| 【Cat NO.】 |
K110216P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
|
| 【Swiss Prot】 |
O15143 |
|
| 【Gene ID】 |
10095 |
|
| 【Application】 |
Blocking Peptide of K110216P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
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Background：
Component of the Arp2/3 complex， a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539， PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm， providing the force for cell motility (PubMed:11741539， PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton， the Arp2/3 complex also promotes actin polymerization in the nucleus， thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization， leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).