Background：

Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones， neurotransmitters， drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds， and therefore their renal excretion， but it can also result in bioactivation to form active metabolites. Sulfates dopamine， small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones， including 3，3’-diiodothyronine， triidothyronine， reverse triiodothyronine and thyroxine.