Background：

The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L)， inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism， and abolishes the suppression of beta-amyloid production by X11L. This protein， together with X11L， may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2， and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene.