 |
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|---|---|---|
| 【ProductName】 |
FTO Antibody Blocking Peptide |
|
| 【Cat NO.】 |
K110456P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
|
| 【Swiss Prot】 |
Q9C0B1 |
|
| 【Gene ID】 |
79068 |
|
| 【Application】 |
Blocking Peptide of K110456P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
|
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Background：
RNA demethylase that mediates oxidative demethylation of different RNA species， such as mRNAs， tRNAs and snRNAs， and acts as a regulator of fat mass， adipogenesis and energy homeostasis (PubMed:22002720， PubMed:26458103， PubMed:28002401， PubMed:30197295， PubMed:26457839， PubMed:25452335). Specifically demethylates N6-methyladenosine (m6A) RNA， the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720， PubMed:26458103， PubMed:30197295， PubMed:26457839， PubMed:25452335). M6A demethylation by FTO affects mRNA expression and stability (PubMed:30197295). Also able to demethylate m6A in U6 small nuclear RNA (snRNA) (PubMed:30197295). Mediates demethylation of N6，2’-O-dimethyladenosine cap (m6A(m))， by demethylating the N6-methyladenosine at the second transcribed position of mRNAs and U6 snRNA (PubMed:28002401， PubMed:30197295). Demethylation of m6A(m) in the 5’-cap by FTO affects mRNA stability by promoting susceptibility to decappi