Background：

Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses， including neutrophil， monocyte， macrophage and mast cell functions， cytoskeleton remodeling in response to extracellular stimuli， phagocytosis， cell adhesion and migration. Promotes mast cell degranulation， release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins， such as MS4A2/FCER1B， FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2， and regulates actin cytoskeleton reorganization， cell spreading and adhesion. Depending on the context， activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling， phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling， normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migrati