 |
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|---|---|---|
| 【ProductName】 |
MBTPS2 Antibody Blocking Peptide |
|
| 【Cat NO.】 |
K110644P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
|
| 【Swiss Prot】 |
O43462 |
|
| 【Gene ID】 |
51360 |
|
| 【Application】 |
Blocking Peptide of K110644P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
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Background：
Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6， ATF6B， SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:11163209， PubMed:10805775). Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment， thereby releasing the N-terminal segment with a portion of the transmembrane segment attached (PubMed:10805775， PubMed:27380894， PubMed:9659902). Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription (PubMed:10805775， PubMed:27380894， PubMed:9659902). Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B) (PubMed:11163209). Involved in intramembrane proteolysis during bone formation (PubMed:27380894).