 |
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|---|---|---|
| 【ProductName】 |
GNL3L Antibody Blocking Peptide |
|
| 【Cat NO.】 |
K110672P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
|
| 【Swiss Prot】 |
Q9NVN8 |
|
| 【Gene ID】 |
54552 |
|
| 【Application】 |
Blocking Peptide of K110672P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
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Background：
Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis， promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination， and hence proteasomal degradation. By acting on MDM2， may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.