 |
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|---|---|---|
| 【ProductName】 |
SIAH2 Antibody Blocking Peptide |
|
| 【Cat NO.】 |
K110799P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
|
| 【Swiss Prot】 |
O43255 |
|
| 【Gene ID】 |
6478 |
|
| 【Application】 |
Blocking Peptide of K110799P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
|
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Background：
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:9334332， PubMed:11483518， PubMed:19224863). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:9334332， PubMed:11483518， PubMed:19224863). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:9334332， PubMed:11483518， PubMed:19224863). Triggers the ubiquitin-mediated degradation of many substrates， including proteins involved in transcription regulation (GPS2， POU2AF1， PML， NCOR1)， a cell surface receptor (DCC)， an antiapoptotic protein (BAG1)， and a protein involved in synaptic vesicle function in neurons (SYP) (PubMed:9334332， PubMed:11483518， PubMed:19224863). Mediates ubiquitination and proteasomal degradation of DYRK