 |
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|---|---|---|
| 【ProductName】 |
BRSK1 Antibody Blocking Peptide |
|
| 【Cat NO.】 |
K111090P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
|
| 【Swiss Prot】 |
Q8TDC3 |
|
| 【Gene ID】 |
84446 |
|
| 【Application】 |
Blocking Peptide of K111090P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
|
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Background：
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B， CDC25C， MAPT/TAU， RIMS1， TUBG1， TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1， acts as a key regulator of polarization of cortical neurons， probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in postmitotic neurons， leading to down-regulate WEE1 activity in polarized neurons. In neurons， localizes to synaptic vesicles and plays a role in neurotransmitter release， possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at ’Ser-131’， leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint r