 |
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|---|---|---|
| 【ProductName】 |
AAK1 Antibody Blocking Peptide |
|
| 【Cat NO.】 |
K111138P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
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| 【Swiss Prot】 |
Q2M2I8 |
|
| 【Gene ID】 |
22848 |
|
| 【Application】 |
Blocking Peptide of K111138P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
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Background：
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:17494869， PubMed:11877457， PubMed:11877461， PubMed:12952931， PubMed:14617351， PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially， may phosphorylate substrates on threonine residues (PubMed:11877457， PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization， promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1， increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124).