Background：

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change， leading to the opening of the cation channel， and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state， characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8， shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.