Background：

Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC， and is involved in the regulation of MAPK8/JNK1 and Ras signaling， Golgi membrane integrity and trafficking， cell survival through NF-kappa-B activation， cell migration， cell differentiation by mediating HDAC7 nuclear export， cell proliferation via MAPK1/3 (ERK1/2) signaling， and plays a role in cardiac hypertrophy， VEGFA-induced angiogenesis， genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues， which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1， inducing RIN1 binding to 14-3-3 proteins YWHAB， YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS， HRAS and KRAS). Acts downstream of the heter