 |
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|---|---|---|
| 【ProductName】 |
HK1 Antibody Blocking Peptide |
|
| 【Cat NO.】 |
K111516P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
|
| 【Swiss Prot】 |
P19367 |
|
| 【Gene ID】 |
3098 |
|
| 【Application】 |
Blocking Peptide of K111516P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
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Background：
Catalyzes the phosphorylation of various hexoses， such as D-glucose， D-glucosamine， D-fructose， D-mannose and 2-deoxy-D-glucose， to hexose 6-phosphate (D-glucose 6-phosphate， D-glucosamine 6-phosphate， D-fructose 6-phosphate， D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate， respectively) (PubMed:1637300， PubMed:25316723， PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PubMed:27374331). When released in the cytosol， N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane， thereby activating the NLRP3 inflammasome (PubMed:27374331).