 |
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|---|---|---|
| 【ProductName】 |
ARHGEF1 Antibody Blocking Peptide |
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| 【Cat NO.】 |
K111520P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
|
| 【Swiss Prot】 |
Q92888 |
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| 【Gene ID】 |
9138 |
|
| 【Application】 |
Blocking Peptide of K111520P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
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Background：
Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915， PubMed:9641916). Acts as GTPase-activating protein (GAP) for GNA12 and GNA13， and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:9641915， PubMed:9641916， PubMed:8810315， PubMed:30521495). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430).