 |
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|---|---|---|
| 【ProductName】 |
OCRL Antibody Blocking Peptide |
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| 【Cat NO.】 |
K111526P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
|
| 【Swiss Prot】 |
Q01968 |
|
| 【Gene ID】 |
4952 |
|
| 【Application】 |
Blocking Peptide of K111526P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
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Background：
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4，5-bisphosphate (PtdIns(4，5)P2) and phosphatidylinositol-3，4，5-bisphosphate (PtdIns(3，4，5)P3)， with the greatest catalytic activity towards PtdIns(4，5)P2 (PubMed:7761412， PubMed:15474001， PubMed:9430698， PubMed:10764818). Able also to hydrolyzes the 4-phosphate of inositol 1，4，5-trisphosphate and of inositol 1，3，4，5-tetrakisphosphate (PubMed:7761412， PubMed:25869668). Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4，5-bisphosphate that is associated with endosomes (PubMed:21971085). Involved in primary cilia assembly (PubMed:22228094， PubMed:22543976). Acts as a regulator of phagocytosis， hydrolyzing PtdIns(4，5)P2 to promote phagosome closure， through attenuation of PI3K signaling (PubMed:22072788).