Background：

The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin， which together with an alpha and a gamma subunit， forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type， and generalized atrophic benign epidermolysis bullosa， diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene.