 |
||
|---|---|---|
| 【ProductName】 |
BRCA1 Antibody Blocking Peptide |
|
| 【Cat NO.】 |
K112839P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
|
| 【Swiss Prot】 |
P38398 |
|
| 【Gene ID】 |
672 |
|
| 【Application】 |
Blocking Peptide of K112839P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
|
|
||
Background：
E3 ubiquitin-protein ligase that specifically mediates the formation of ’Lys-6’-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:12890688， PubMed:14976165， PubMed:16818604， PubMed:17525340， PubMed:12887909， PubMed:10500182， PubMed:19261748).It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688).The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair， ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688， PubMed:14976165， PubMed:20351172).Regulates centrosomal microtubule nucleation (PubMed:18056443).Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175， PubMed:12183412， PubMed:11836499， PubMed:19261748).Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909).Inhibits