Background：

Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin， modulates its rate of internalization and directs its intracellular trafficking?;Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels， heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling， resulting in by platelet cytoskeleton organization maintenance ;During the axon guidance process， required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons