 |
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|---|---|---|
| 【ProductName】 |
CMTM8 Antibody Blocking Peptide |
|
| 【Cat NO.】 |
K113113P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
|
| 【Swiss Prot】 |
Q8IZV2 |
|
| 【Gene ID】 |
152189 |
|
| 【Application】 |
Blocking Peptide of K113113P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
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Background：
CMTM8， also known as CKLFSF8， is a member of the chemokine-like factor superfamily (CKLFSF).Proteins of this family share similarity with both the chemokine and the transmembrane 4 superfamilies. CMTM8 is an attenuator of EGF-induced signaling (PMID: 16263120).Overexpression of CMTM8 accelerates ligand-induced clearance of EGFR from the cell surface and induces apoptosis via caspase-dependent and -independent pathways (PMID: 17149703).An alternative splice form of CMTM8， CMTM8-v2， arises from a deletion of exon 2. CMTM8-v2 maintains the ability to induce apoptosis (PMID: 17681841).