Background：

This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel， it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots， there is currently no sequence available to confirm transcript variants for this gene.