Background：

This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit， gp130， to form a receptor complex that mediates the action of the leukemia inhibitory factor， a polyfunctional cytokine that is involved in cellular differentiation， proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2， a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene， t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1， is associated with salivary gland pleiomorphic adenoma， a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene.