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Anti-PHKA1/2 Polyclonal Antibody - Cy3.5
Cat: K112758P - Cy3.5
Summary:
【Product name】:Anti-PHKA1/2 Polyclonal Antibody - Cy3.5 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:5255/5256 【Swiss Prot】:P46020/P46019
【Observed】:140kDa
【Tested applications】:IHC,WB
【Recommended dilution】:WB 1:2000-5000. IHC 1:25-100.
【Immunogen】:A synthetic peptide of Human PHKA1/2
【Public Immunogen Range】:40-90/1223aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the skeletal muscle isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9D, also known as X-linked muscle glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. A pseudogene has been found on chromosome 1.
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