Anti-DENND2B Polyclonal Antibody
Cat: K112812P
Summary:
| 【Product name】：Anti-DENND2B Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：6764 | 【Swiss Prot】：P78524 |
| 【Species reactivity】：Human;Mouse | |
| 【Tested applications】：WB;IHC | |
| 【Immunogen】：A synthetic peptide of human DENND2B | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008].
Verified picture:
Western blot analysis with DENND2B antibody diluted at 1:3000;Lane: SH-SY5Y,293T,HepG2.
Immunohistochemistry of paraffin-embedded human colorectal cancer with DENND2B antibody diluted at 1:50.